Antibody therapies ineffective against Omicron variant BQ.1.1, says study


Therapies for Covid-19 infections have enormously elevated possibilities of affected person survival for the reason that begin of the pandemic, and but researchers imagine one key type of remedy will not work against infections with a brand new subvariant.

Omicron BQ.1.1, which together with BQ.1 now makes up for almost all of infections within the United States and is quickly spreading in different nations, is proof against presently authorized antibody therapies, the German Primate Center analysis institute says.

The, printed within the The Lancet Infectious Diseases scientific journal in November, calls on docs to keep away from relying solely on antibody therapy in areas the place BQ.1.1 is extremely prevalent.

When treating contaminated high-risk sufferers, docs also needs to think about different medication equivalent to paxlovid, mentioned study chief Markus Hoffmann.

The researchers imagine that new antibody therapies will now additionally must be developed as a way to keep the well being care arsenal for combating severe instances of Covid-19.

In their laboratory exams on cell cultures, the researchers discovered that BQ.1.1 may neither be neutralised by particular person antibodies nor by antibody cocktails.

BQ.1.1 is simply the newest subvariant of Sars-CoV-2 to indicate resistance to current therapy strategies for coronavirus infections. The reason for the resistance is the mutation of the so-called spike protein of the coronavirus, the researchers mentioned.

“The ever-increasing growth of resistance to Sars-CoV-2 variants makes it essential to develop new antibody therapies which might be significantly tailored to the presently circulating and future virus variants,” defined Stefan Pöhlmann, head of the Department of Infection Biology on the Primate Centre. – dpa

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